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A persistent sad, anxious or "empty" mood
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Sleeping too little or sleeping too much
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Reduced appetite and weight loss, or increased appetite and weight gain
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Loss of interest or pleasure in activities once enjoyed
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Restlessness or irritability
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Persistent physical symptoms that don't respond to treatment [such as headaches, chronic pain, or constipation and other digestive disorders]
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Difficulty concentrating, remembering, or making decisions
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Fatigue or loss of energy
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Feeling guilty, hopeless or worthless
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Thoughts of death or suicide
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